β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

The Gram-negative bacterial envelope is an essential interface between the intracellular
and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the …

The larva of the greater wax moth Galleria mellonella is an increasingly popular model for
assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents …

The emergence of ultra-large screening libraries, filled to the brim with billions of readily
available compounds, poses a growing challenge for docking-based virtual screening …

Infections caused by Klebsiella pneumoniae are a major public health threat. Extensively
drug-resistant and even pan-resistant strains have been reported. Understanding K …

Bacterial persister cells—a metabolically dormant subpopulation tolerant to antimicrobials—
contribute to chronic infections and are thought to evade host immunity. In this work, we …

Gram-negative bacteria are contained by an envelope composed of inner and outer-
membranes with the peptidoglycan (PG) layer between them. Protein translocation across …

The cell envelope of Gram-negative bacteria belonging to the Burkholderia cepacia complex
(Bcc) presents unique restrictions to antibiotic penetration. As a consequence, Bcc species …

Intrinsic resistance to macrolides in Gram-negative bacteria is primarily attributed to the low
permeability of the outer membrane, though the underlying genetic and molecular …

Antibiotic resistance has emerged as a serious threat to global public health in recent years.
Lack of novel antimicrobials, especially new classes of compounds, further aggravates the …