Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Causes and consequences of RNA polymerase II stalling during transcript elongation
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
[HTML][HTML] Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …
R loops: new modulators of genome dynamics and function
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
Causes and consequences of replication stress
MK Zeman, KA Cimprich - Nature cell biology, 2014 - nature.com
Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …
stability, cell survival and human disease. Generation of aberrant replication fork structures …
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …
Senataxin resolves RNA: DNA hybrids forming at DNA double-strand breaks to prevent translocations
Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …
Direct visualization of transcription-replication conflicts reveals post-replicative DNA: RNA hybrids
H Stoy, K Zwicky, D Kuster, KS Lang… - Nature Structural & …, 2023 - nature.com
Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-
loops were linked to head-on TRCs and proposed to obstruct replication fork progression …
loops were linked to head-on TRCs and proposed to obstruct replication fork progression …