SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …

Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …

The sigma 2 receptor (σ2R) was described pharmacologically more than three decades ago,
but its molecular identity remained obscure until recently when it was identified as …

One of the first signs of viral infection is body-wide aches and pain. Although this type of pain
usually subsides, at the extreme, viral infections can induce painful neuropathies that can …

Injury-induced sensitization of nociceptors contributes to pain states and the development of
chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of …

Inflammation and pain are intertwined responses to injury, infection, or chronic diseases.
While acute inflammation is essential in determining pain resolution and opioid analgesia …

Normal spermatogenic processes require the scrotal temperature to be lower than that of the
body as excessive heat affects spermatogenesis in the testes, reduces sperm quality and …

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …

Dysfunction in regulation of mRNA translation is an increasingly recognized characteristic of
many diseases and disorders, including cancer, diabetes, autoimmunity …

In multiple cell types, mRNAs are transported to subcellular compartments, where local
translation enables rapid, spatially localized, and specific responses to external stimuli …