Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Intense interest in the'Warburg effect'has been revived by the discovery that hypoxia-
inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic …

The pH value in the wound milieu plays a key role in cellular processes and cell cycle
processes involved in the process of wound healing. Here, a microfluidic assembly …

It is known that pH has a role to play in wound healing. In particular, pH has been shown to
affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity …

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is
heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production …

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …

Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …

While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

Tumor metabolism consists of complex interactions between oxygenation states,
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …

Differences in global levels of histone acetylation occur in normal and cancer cells, although
the reason why cells regulate these levels has been unclear. Here we demonstrate a role for …