Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Multiple changes occur in hormonal regulation with aging and across various endocrine
organs. These changes are associated with multiple age-related disorders and diseases. A …

Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in
recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue …

Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …

Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic
inflammation. Recent evidence suggests that an increased burden of senescent cells (SCs) …

In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …