Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; …

Background Alcohol use is a leading risk factor for death and disability, but its overall
association with health remains complex given the possible protective effects of moderate …

Background The health risks associated with moderate alcohol consumption continue to be
debated. Small amounts of alcohol might lower the risk of some health outcomes but …

Background Understanding the temporal trends in the burden of overall and type-specific
cardiovascular diseases (CVDs) in youths and young adults and its attributable risk factors is …

Importance A previous meta-analysis of the association between alcohol use and all-cause
mortality found no statistically significant reductions in mortality risk at low levels of …

Background Frailty is associated with older age and multimorbidity (two or more long-term
conditions); however, little is known about its prevalence or effects on mortality in younger …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the …

Cross-sectional studies have demonstrated strong associations between physical frailty and
depression. However, the evidence from prospective studies is limited. Here, we analyze …

BackgroundThe Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides
an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden …

Summary Background In September, 2015, the UN General Assembly established the
Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets …