Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

The blood–brain barrier (BBB) has a significant contribution to homeostasis and protection
of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the …

The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

The human central nervous system (CNS) vasculature expresses a distinctive barrier
phenotype, the blood–brain barrier (BBB). As the BBB contributes to low efficiency in CNS …

Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of
human tissue on an engineered platform. In the case of brain tissue, structural connections …

Engineered human mini-brains, made possible by knowledge from the convergence of
precision microengineering and cell biology, permit systematic studies of complex …

Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …

Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological
problems. Unfortunately, the precise mechanisms remain unknown, and there are no …