AT2 Receptor and Tissue Injury: Therapeutic Implications

P Namsolleck, C Recarti, S Foulquier… - Current hypertension …, 2014‏ - Springer
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …

The angiotensin II type 2 receptor in brain functions: an update

MO Guimond, N Gallo-Payet - International journal of …, 2012‏ - Wiley Online Library
Angiotensin II (Ang II) is the main active product of the renin‐angiotensin system (RAS),
mediating its action via two major receptors, namely, the Ang II type 1 (AT1) receptor and the …

How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?

MO Guimond, N Gallo-Payet - Frontiers in endocrinology, 2012‏ - frontiersin.org
The angiotensin type 2 (AT2) receptor of angiotensin II has long been thought to be limited
to few tissues, with the primary effect of counteracting the angiotensin type 1 (AT1) receptor …

pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A

MD Williams, JS Morgan, MT Bullock… - American Journal …, 2024‏ - journals.physiology.org
Phenotypic transformation of vascular smooth muscle (VSM) from a contractile state to a
synthetic, proliferative state is a hallmark of cardiovascular disease (CVD). In CVD, diseased …

Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina

LE Downie, K Vessey, A Miller, MM Ward, MJ Pianta… - Neuroscience, 2009‏ - Elsevier
The bio-active peptide, angiotensin II (Ang II), has been suggested to exert a
neuromodulatory effect on inner retinal neurons. In this study, we examined the distribution …

Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite …

MO Guimond, C Wallinder, M Alterman… - European journal of …, 2013‏ - Elsevier
There is increasing evidence that angiotensin II (Ang II), through binding to the type 2 (AT2)
receptor may have beneficial effects in various physiological and pathological situations …

Role of Tyrosine Kinase Receptors in Angiotensin II AT2 Receptor Signaling: Involvement in Neurite Outgrowth and in p42/p44mapk Activation in NG108-15 Cells

B Plouffe, MO Guimond, H Beaudry… - Endocrinology, 2006‏ - academic.oup.com
NG108–15 cells, which have a rounding-up morphology when cultured in serum-
supplemented medium, extend neurites when stimulated for 3 d with angiotensin II (Ang II) …

1,800 MHz radiofrequency electromagnetic irradiation impairs neurite outgrowth with a decrease in Rap1-GTP in primary mouse hippocampal neurons and neuro2a …

Y Li, P Deng, C Chen, Q Ma, H Pi, M He, Y Lu… - Frontiers in public …, 2021‏ - frontiersin.org
Background: With the global popularity of communication devices such as mobile phones,
there are increasing concerns regarding the effect of radiofrequency electromagnetic …

The therapeutic potential of renin angiotensin aldosterone system (RAAS) in chronic pain: from preclinical studies to clinical trials

F Bessaguet, L Magy, A Desmoulière… - Expert Review of …, 2016‏ - Taylor & Francis
The prevalence rate of chronic pain is 15% to 25% in adults while the therapeutic arsenal is
still insufficient, especially in relieving neuropathic pain. Peripheral pain transmission is …

Fyn is involved in angiotensin II type 2 receptor-induced neurite outgrowth, but not in p42/p44mapk in NG108-15 cells

MO Guimond, C Roberge, N Gallo-Payet - Molecular and Cellular …, 2010‏ - Elsevier
In NG108-15 cells, activation of p42/p44mapk is essential for induction of neurite outgrowth
by angiotensin II (Ang II) type 2 receptor (AT2). The aim was to verify whether Fyn, a member …