pH-sensitive nano-systems for drug delivery in cancer therapy

J Liu, Y Huang, A Kumar, A Tan, S **, A Mozhi… - Biotechnology …, 2014 - Elsevier
Nanotechnology has been widely used in the development of new strategies for drug
delivery and cancer therapy. Compared to traditional drug delivery systems, nano-based …

Pharmacokinetics and biodistribution of nanoparticles

SD Li, L Huang - Molecular pharmaceutics, 2008 - ACS Publications
Nanoparticles show their promise for improving the efficacy of drugs with a narrow
therapeutic window or low bioavailability, such as anticancer drugs and nucleic acid-based …

Block copolymer micelles: preparation, characterization and application in drug delivery

G Gaucher, MH Dufresne, VP Sant, N Kang… - Journal of controlled …, 2005 - Elsevier
Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or
oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic …

pH-sensitive biomaterials for drug delivery

S Zhuo, F Zhang, J Yu, X Zhang, G Yang, X Liu - Molecules, 2020 - mdpi.com
The development of precise and personalized medicine requires novel formulation
strategies to deliver the therapeutic payloads to the pathological tissues, producing …

Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility

RK O'Reilly, CJ Hawker, KL Wooley - Chemical Society Reviews, 2006 - pubs.rsc.org
Supramolecular self assembly techniques have provided a versatile means by which to
selectively assemble polymer molecules into well-defined three dimensional core–shell …

Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review

T Ramasamy, HB Ruttala, B Gupta, BK Poudel… - Journal of Controlled …, 2017 - Elsevier
This review focuses on the smart chemistry that has been utilized in develo** polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

Toward 'smart'nano-objects by self-assembly of block copolymers in solution

J Rodriguez-Hernandez, F Chécot, Y Gnanou… - Progress in polymer …, 2005 - Elsevier
In recent years, the synthesis and analysis of novel copolymer-based nanomaterials in
solution have been extensively pursued. The interest in such structures lies in the fact that …

Design and development of polymeric micelles with cleavable links for intracellular drug delivery

H Wei, RX Zhuo, XZ Zhang - Progress in polymer Science, 2013 - Elsevier
Driven by the urgent need in practical applications of stimuli-responsive nano-carriers for
intracellular drug delivery, the design and development of advanced polymeric micelles …

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

AE Felber, MH Dufresne, JC Leroux - Advanced drug delivery reviews, 2012 - Elsevier
Titratable polyanions, and more particularly polymers bearing carboxylate groups, have
been used in recent years to produce a variety of pH-sensitive colloids. These polymers …

Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review

Z Wang, X Deng, J Ding, W Zhou, X Zheng… - International journal of …, 2018 - Elsevier
During the past decades, chemotherapy has been regarded as the most effective method for
tumor therapy, but still faces significant challenges, such as poor tumor selectivity and …