Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Aims: Lipid peroxidation occurring in lung adenocarcinoma (LUAD) cells leads to
ferroptosis. Lysophosphatidylcholine acyl-transferase 3 (LPCAT3) plays a key role in …

The past three decades have yielded a wealth of information regarding the chromatin
regulatory mechanisms that control transcription. The “histone code” hypothesis—which …

Simple Summary Through their regulatory effects on gene expression, histone
acetyltransferases have been implicated in the normal physiological activities and genesis …

Epigenetic modifications are defined as heritable changes in gene activity that do not
involve changes in the underlying DNA sequence. The oncogenic process is driven by the …