Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …

Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood
glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied …

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been suggested to
play a key role in insulin resistance development. Reactive oxygen species (ROS) …

Diabetes profoundly alters fuel metabolism; both insulin deficiency and insulin resistance
are characterized by inefficient mitochondrial coupling and excessive production of reactive …

Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …

Skeletal muscle is a plastic tissue capable of adapting and mal-adapting to physical activity
and diet. The response of skeletal muscle to adaptive stimuli, such as exercise, can be …

The purpose of this study is to determine whether moderate aerobic exercise training
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …