Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X ** of truncated O-glycans in cancers of epithelial and non-epithelial origin
TB Rømer, MKM Aasted, S Dabelsteen… - British Journal of …, 2021 - nature.com
Background Novel immunotherapies targeting cancer-associated truncated O-glycans Tn
(GalNAcα-Ser/Thr) and STn (Neu5Acα2–6GalNacα-Ser/Thr) are promising strategies for …

Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin

SA Dusoswa, J Verhoeff, E Abels… - Proceedings of the …, 2020 - pnas.org
Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed
to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor …

Molecular recognition in C‐type lectins: the cases of DC‐SIGN, Langerin, MGL, and L‐sectin

P Valverde, JD Martínez, FJ Cañada, A Arda… - …, 2020 - Wiley Online Library
Carbohydrates play a pivotal role in intercellular communication processes. In particular,
glycan antigens are key for sustaining homeostasis, hel** leukocytes to distinguish …

Role of lectin microarrays in cancer diagnosis

P Syed, K Gidwani, H Kekki, J Leivo, K Pettersson… - …, 2016 - Wiley Online Library
The majority of cell differentiation associated tumor markers reported to date are either
glycoproteins or glycolipids. Despite there being a large number of glycoproteins reported …

Tn antigen expression contributes to an immune suppressive microenvironment and drives tumor growth in colorectal cancer

LAM Cornelissen, A Blanas, A Zaal… - Frontiers in …, 2020 - frontiersin.org
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been
correlated to poor prognosis and metastasis in multiple cancer types. However, the exact …

MGL receptor and immunity: when the ligand can make the difference

IG Zizzari, C Napoletano, F Battisti… - Journal of …, 2015 - Wiley Online Library
C‐type lectin receptors (CLRs) on antigen‐presenting cells (APCs) facilitate uptake of
carbohydrate antigens for antigen presentation, modulating the immune response in …

Role of Truncated O-GalNAc Glycans in Cancer Progression and Metastasis in Endocrine Cancers

D Pinto, R Parameswaran - Cancers, 2023 - mdpi.com
Simple Summary The surface of a human cell is coated by glycans, which play an important
role in many of the physiological processes that include cell–cell communication, interaction …

[HTML][HTML] Advances in the immunomodulatory properties of glycoantigens in cancer

V da Costa, T Freire - Cancers, 2022 - mdpi.com
Simple Summary This work reviews the role of aberrant glycosylation in cancer cells during
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …