Mobile genetic elements associated with antimicrobial resistance

SR Partridge, SM Kwong, N Firth… - Clinical microbiology …, 2018 - journals.asm.org
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Deciphering the mobility and bacterial hosts of antibiotic resistance genes under antibiotic selection pressure by metagenomic assembly and binning approaches

R Zhao, K Yu, J Zhang, G Zhang, J Huang, L Ma… - Water research, 2020 - Elsevier
The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …

Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential

C Pal, J Bengtsson-Palme, E Kristiansson… - BMC genomics, 2015 - Springer
Background Antibacterial biocides and metals can co-select for antibiotic resistance when
bacteria harbour resistance or tolerance genes towards both types of compounds. Despite …

Evolution of plasmid mobility: origin and fate of conjugative and nonconjugative plasmids

C Coluzzi, MP Garcillán-Barcia… - Molecular Biology …, 2022 - academic.oup.com
Conjugation drives the horizontal transfer of adaptive traits across prokaryotes. One-fourth of
the plasmids encode the functions necessary to conjugate autonomously, the others being …

Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

The role of integrative and conjugative elements in antibiotic resistance evolution

J Botelho, H Schulenburg - Trends in microbiology, 2021 - cell.com
Mobile genetic elements (MGEs), such as plasmids and integrative and conjugative
elements (ICEs), are main drivers for the spread of antibiotic resistance (AR). Coevolution …

Fungicide exposure accelerated horizontal transfer of antibiotic resistance genes via plasmid-mediated conjugation

H Zhang, J Song, Z Zheng, T Li, N Shi, Y Han, L Zhang… - Water Research, 2023 - Elsevier
Co-pollution of soil with pesticide residues and antibiotic resistance genes (ARGs) is
increasing due to the substantial usage of pesticides and organic fertilizers in greenhouse …

Phylogenetic background and habitat drive the genetic diversification of Escherichia coli

M Touchon, A Perrin, JAM De Sousa, B Vangchhia… - PLoS …, 2020 - journals.plos.org
Escherichia coli is mostly a commensal of birds and mammals, including humans, where it
can act as an opportunistic pathogen. It is also found in water and sediments. We …

Identification of protein secretion systems in bacterial genomes

SS Abby, J Cury, J Guglielmini, B Néron, M Touchon… - Scientific reports, 2016 - nature.com
Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …