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Antibiotics in the clinical pipeline as of December 2022
The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …
resistant bacterial infections has clearly attracted global attention, with a range of existing …
Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application
T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …
[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria
RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …
Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment
T Zhang, T Tian, R Zhou, S Li, W Ma, Y Zhang, N Liu… - Nature protocols, 2020 - nature.com
Although organic nanomaterials and inorganic nanoparticles possess inherent flexibility,
facilitating functional modification, increased intracellular uptake and controllable drug …
facilitating functional modification, increased intracellular uptake and controllable drug …
Antibiotics in the clinical pipeline in October 2019
MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects
TJ Foster - FEMS microbiology reviews, 2017 - academic.oup.com
The major targets for antibiotics in staphylococci are (i) the cell envelope,(ii) the ribosome
and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery …
and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery …
Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus
S Schäper, AD Brito, BM Saraiva, GR Squyres… - Nature …, 2024 - nature.com
Bacterial cell division requires recruitment of peptidoglycan (PG) synthases to the division
site by the tubulin homologue, FtsZ. Septal PG synthases promote septum growth. FtsZ …
site by the tubulin homologue, FtsZ. Septal PG synthases promote septum growth. FtsZ …
Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division
The mechanism by which bacteria divide is not well understood. Cell division is mediated by
filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to …
filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to …
Antibiotics and bacterial resistance in the 21st century
RJ Fair, Y Tor - Perspectives in medicinal chemistry, 2014 - journals.sagepub.com
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …
the past several decades. In this review the factors that have been linked to this …