The emergence of spatial multi-omics has helped address the limitations of single-cell
sequencing, which often leads to the loss of spatial context among cell populations …

Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …

Fragile X messenger ribonucleoprotein 1 (FMRP) is a widely expressed RNA binding
protein involved in several steps of mRNA metabolism. Mutations in the FMR1 gene …

The spatial and temporal dynamics of forces in cells coordinate essential behaviors like
division, polarization, and migration. While intracellular signaling initiates contractile ring …

The cGAS-STING signaling pathway is indeed a pivotal component of the immune system
and serve as a crucial link between innate and adaptive immune responses. STING is …

Okazaki fragment maturation (OFM) stands as a pivotal DNA metabolic process, crucial for
genome integrity and cell viability. Dysregulation of OFM leads to DNA single-strand breaks …

Immune checkpoint inhibitor (ICI) therapy is a promising anti‐tumor therapeutic strategy;
however, its efficacy in solid tumors is limited. Chromosome missegregation is common in …

Highlights•Cell-autonomous tumor suppressive pathways are linked to innate immune
responses.•Macrophages sense and respond to outputs of cell-intrinsic barriers to …

Despite the development of HER2‐targeting drugs such as trastuzumab and T‐DXd,
treatment resistance is a substantial challenge, often leading to relapse and distant …

Aging is a significant risk factor for cancer which is due, in part, to heightened genomic
instability. Mitotic surveillance proteins such as BubR1 play a pivotal role in ensuring …