Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted
therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we …

Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …

Galectin-3 is a member of the family of β-galactoside-binding lectins characterized by
evolutionarily conserved sequences defined by structural similarities in their carbohydrate …

Unlike traditional cancer therapies, such as surgery, radiation and chemotherapy that are
typically non-specific, cancer immunotherapy harnesses the high specificity of a patient's …

Glycosylation is a very frequent and functionally important post-translational protein
modification that undergoes profound changes in cancer. Growth and death factor receptors …

Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

This review discusses the role of galectin-1 in the tumor microenvironment. First, the
structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin …