Designing microbial cell factories for the production of chemicals
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …
as an essential alternative to address pressing environmental issues arising from our heavy …
Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0
Genome-scale metabolic models (GEMs) are computational representations that enable
mathematical exploration of metabolic behaviors within cellular and environmental …
mathematical exploration of metabolic behaviors within cellular and environmental …
Abnormal brain cholesterol homeostasis in Alzheimer's disease—a targeted metabolomic and transcriptomic study
VR Varma, H Büşra Lüleci, AM Oommen… - npj Aging and …, 2021 - nature.com
The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
Systematic multi-omics integration (MOI) approach in plant systems biology
Across all facets of biology, the rapid progress in high-throughput data generation has
enabled us to perform multi-omics systems biology research. Transcriptomics, proteomics …
enabled us to perform multi-omics systems biology research. Transcriptomics, proteomics …
Human systems biology and metabolic modelling: a review—from disease metabolism to precision medicine
C Angione - BioMed research international, 2019 - Wiley Online Library
In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …
[HTML][HTML] Advances in flux balance analysis by integrating machine learning and mechanism-based models
The availability of multi-omics data sets and genome-scale metabolic models for various
organisms provide a platform for modeling and analyzing genotype-to-phenotype …
organisms provide a platform for modeling and analyzing genotype-to-phenotype …
Multiscale models quantifying yeast physiology: towards a whole-cell model
The yeast Saccharomyces cerevisiae is widely used as a cell factory and as an important
eukaryal model organism for studying cellular physiology related to human health and …
eukaryal model organism for studying cellular physiology related to human health and …
Transcriptome-guided parsimonious flux analysis improves predictions with metabolic networks in complex environments
The metabolic responses of bacteria to dynamic extracellular conditions drives not only the
behavior of single species, but also entire communities of microbes. Over the last decade …
behavior of single species, but also entire communities of microbes. Over the last decade …
Integrating thermodynamic and enzymatic constraints into genome-scale metabolic models
Stoichiometric genome-scale metabolic network models (GEMs) have been widely used to
predict metabolic phenotypes. In addition to stoichiometric ratios, other constraints such as …
predict metabolic phenotypes. In addition to stoichiometric ratios, other constraints such as …