Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …

Leber congenital amaurosis (LCA) is an inherited retinal dystrophy that causes childhood
blindness. Photoreceptors are especially sensitive to an intronic mutation in the cilia-related …

The axoneme of motile cilia is the largest macromolecular machine of eukaryotic cells. In
humans, impaired axoneme function causes a range of ciliopathies. Axoneme assembly …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …