[HTML][HTML] The diverse functionality of NQO1 and its roles in redox control
D Ross, D Siegel - Redox Biology, 2021 - Elsevier
In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …
processes and potential roles in redox control that are currently emerging. NQO1 has …
Stearoyl coenzyme A desaturase-1: multitasker in cancer, metabolism, and ferroptosis
Cancer progression is a highly balanced process and is maintained by a sequence of finely
tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that …
tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that …
Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch
D Ross, D Siegel - Frontiers in physiology, 2017 - frontiersin.org
NQO1 is one of the two major quinone reductases in mammalian systems. It is highly
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
The sirtuins are a family of highly conserved NAD+-dependent deacetylases that act as
cellular sensors to detect energy availability and modulate metabolic processes. Two …
cellular sensors to detect energy availability and modulate metabolic processes. Two …
Redox regulation of mitochondrial function
DE Handy, J Loscalzo - Antioxidants & redox signaling, 2012 - liebertpub.com
Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …
Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration
M Ortiz, SA Soto-Alarcón, P Orellana… - Digestive and Liver …, 2020 - Elsevier
Objective Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative
stress and mitochondrial dysfunction, which can be eluded by the co-administration of the …
stress and mitochondrial dysfunction, which can be eluded by the co-administration of the …
[PDF][PDF] Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies
GS Oh, HJ Kim, AH Shen, SB Lee… - Electrolytes & Blood …, 2014 - synapse.koreamed.org
Cisplatin is one of the most widely used and highly effective drug for the treatment of various
solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and …
solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and …
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Type 2 diabetes is a complex disease that is marked by the dysfunction of glucose and lipid
metabolism. Hepatic insulin resistance is especially pathogenic in type 2 diabetes, as it …
metabolism. Hepatic insulin resistance is especially pathogenic in type 2 diabetes, as it …
NAD (P) H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy
D Qiu, S Song, Y Wang, Y Bian, M Wu, H Wu… - Journal of Translational …, 2022 - Springer
Background Diabetic nephropathy (DN) is one of the main complications of diabetes, and
oxidative stress plays an important role in its progression. NAD (P) H: quinone …
oxidative stress plays an important role in its progression. NAD (P) H: quinone …