Polymer nanoparticles for the intravenous delivery of anticancer drugs: the checkpoints on the road from the synthesis to clinical translation

R Ferrari, M Sponchioni, M Morbidelli, D Moscatelli - Nanoscale, 2018 - pubs.rsc.org
In this review article we discuss some of the key aspects concerning the development of a
polymer-based nanoparticle formulation for intravenous drug delivery. Since numerous …

Strategies to combine ROP with ATRP or RAFT polymerization for the synthesis of biodegradable polymeric nanoparticles for biomedical applications

UC Palmiero, M Sponchioni, N Manfredini… - Polymer …, 2018 - pubs.rsc.org
The architecture, composition and molecular weight (MW) of polymers and copolymers
made via free radical polymerization are important parameters that affect the end-use of both …

In situ spectroscopic studies of highly transparent nanoparticle dispersions enable assessment of trithiocarbonate chain-end fidelity during RAFT dispersion …

EJ Cornel, S van Meurs, T Smith… - Journal of the …, 2018 - ACS Publications
We report the synthesis of highly transparent poly (stearyl methacrylate)-poly (2, 2, 2-
trifluoroethyl methacrylate)(PSMA–PTFEMA) diblock copolymer nanoparticles via …

Cathepsin B-responsive prodrugs for cancer-targeted therapy: Recent advances and progress for clinical translation

SI Jeon, S Yang, MK Shim, K Kim - Nano Research, 2022 - Springer
The cathepsin B-responsive prodrugs are promising strategies to reduce the serious
adverse effects of anticancer drugs by improving the cancer selectivity that can be …

HPMA-based polymeric conjugates in anticancer therapeutics

S Rani, U Gupta - Drug discovery today, 2020 - Elsevier
Highlights•HPMA (N-2-hydroxypropylmethacrylamide) is an emerging polymeric alternative
for drug delivery applications.•HPMA can be potentially conjugated to develop copolymers …

Current trends in the development of HPMA-based block copolymeric nanoparticles for their application in drug delivery

Y Bobde, S Biswas, B Ghosh - European Polymer Journal, 2020 - Elsevier
Abstract N-(2-hydroxypropyl) methacrylamide-based block copolymers (pHPMA) have
received attention due to their hydrophilicity, non-immunogenicity, biocompatibility and …

pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

M Kong, X Peng, H Cui, P Liu, B Pang, K Zhang - RSC advances, 2020 - pubs.rsc.org
Biodegradable nanoparticles (NPs) have shown great promise as intracellular imaging
probes, nanocarriers and drug delivery vehicles. In this study, we designed and prepared …

Thermoresponsive Modular Nano-Objects Via RAFT Dispersion Polymerization in a Non-Polar Solvent

G Gardoni, N Manfredini, M Monzani… - ACS Applied Polymer …, 2022 - ACS Publications
Thermoresponsive polymer nano-objects able to dynamically change their morphology in
response to modifications in the local temperature are finding growing attention for …

Valorisation of glycerol and CO2 to produce biodegradable polymer nanoparticles with a high percentage of bio-based components

A Zanoni, G Gardoni, M Sponchioni… - Journal of CO2 Utilization, 2020 - Elsevier
The biodiesel industry has grown rapidly in the last years, leading to the production of 88
000 tons of waste glycerol in 2018. Glycerol is a bio-derived molecule already exploited in …

Sequential post-polymerization modification of a pentafluorophenyl ester-containing homopolymer: a convenient route to effective pH-responsive nanocarriers for …

Y Pinyakit, T Palaga, S Kiatkamjornwong… - Journal of Materials …, 2020 - pubs.rsc.org
Recently, pH-responsive polymeric micelles have gained significant attention as effective
carriers for anti-cancer drug delivery. Herein, pH-responsive polymeric micelles were …