The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Despite significant advances in early detection and treatment, breast cancer still remains a
major cause of morbidity and mortality for women. Our understanding of the molecular …

BACKGROUND How do the different cell types in our bodies maintain their distinctive and
characteristic sizes? Although much is known about the signaling networks that stimulate or …

Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …

Waddington's epigenetic landscape is probably the most famous and most powerful
metaphor in developmental biology. Cells, represented by balls, roll downhill through a …

Quantitative single-cell time-lapse microscopy is a powerful method for analyzing gene
circuit dynamics and heterogeneous cell behavior. We describe the application of this …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Computational modeling and the theory of nonlinear dynamical systems allow one to not
simply describe the events of the cell cycle, but also to understand why these events occur …

Cell division is thought to be initiated by cyclin-dependent kinases (Cdks) inactivating key
transcriptional inhibitors. In budding yeast, the G1 cyclin Cln3-Cdk1 complex is thought to …