According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Recent advances in efficiency and ease of implementation have rekindled interest in ion
mobility spectrometry, a technique that separates gas phase ions by their size and shape …

In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak
widths in the range of seconds, whereas mass spectra are acquired in about 100 …

We present a data-independent acquisition mass spectrometry method, ultradefinition (UD)
MSE. This approach utilizes ion mobility drift time-specific collision-energy profiles to …

Unbiased data-independent acquisition (DIA) strategies have gained increased popularity in
the field of quantitative proteomics. The integration of ion mobility separation (IMS) into DIA …

Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for
identification, characterization, and quantification of proteins that are integral components of …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–
MS) and related techniques with the main focus on recent developments in the last decade …

One difficulty in using ion mobility (IM) mass spectrometry (MS) to improve the specificity of
peptide ion assignments is that IM separations are performed using a range of pressures …

Ion mobility can add a dimension to LC-MS based shotgun proteomics which has the
potential to boost proteome coverage, quantification accuracy and dynamic range. Required …