Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological
condition whose manifestation is affected by complex environmental and genetic …

Maintenance dialysis patients experience a high burden of physical and emotional
symptoms that directly affect their quality of life and health care utilization. In this review, we …

Background In 2003, following a workshop at the National Institutes of Health, the
International Restless Legs Syndrome Study Group (IRLSSG) developed updated …

A major role of genetic factors in the risk of develo** restless legs syndrome (RLS) is
supported by the high frequency of positive family history of RLS in patients affected with this …

RLS is a genetically heterogeneous complex trait with high prevalence but large phenotype
variability. Current theories of RLS pathophysiology emphasize brain iron deficiency with …

Receptor‐type protein tyrosine phosphatase, receptor type D (PTPRD) has likely roles as a
neuronal cell adhesion molecule and synaptic specifier. Interest in its neurobiology and …

Abstract Study Objectives: To examine association between periodic leg movements (PLM)
and 13 single nucleotide polymorphisms (SNPs) in 6 loci known to increase risk of restless …

Restless legs syndrome (RLS)(or Willis–Ekbom disease) is a neurological disorder with high
prevalence among the end-stage renal disease population. This is one of the most …

Symptoms of restless legs syndrome (RLS) are common in patients with chronic kidney
disease (CKD) on dialysis; symptoms of RLS are estimated to affect up to 25% of patients on …

Summary Restless Legs Syndrome (RLS), first chronicled by Willis in 1672 and described in
more detail by Ekbom in 1945 [1], is a prevalent sensorimotor neurological disorder (5 …