Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Pharmaceutically important polyketides such as avermectin are mainly produced as
secondary metabolites during the stationary phase of growth of Streptomyces species in …

Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Streptomyces coelicolor is the genetically best characterized species of a populous genus
belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil …

Well-characterized promoters are essential tools for metabolic engineering and synthetic
biology. In Streptomyces coelicolor, the native kasO p is a temporally expressed promoter …

Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Polycyclic tetramate macrolactams (PTMs) are a widely distributed class of natural products
with important biological activities. However, many of these PTMs have not been …

Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …