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[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers
J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
3D printed oral solid dosage form: Modified release and improved solubility
N Wang, H Shi, S Yang - Journal of Controlled Release, 2022 - Elsevier
Oral solid dosage form is currently the most common used form of drug. 3D Printing, also
known as additive manufacturing (AM), can quickly print customized and individualized oral …
known as additive manufacturing (AM), can quickly print customized and individualized oral …
Considerations in the development of physically stable high drug load API-polymer amorphous solid dispersions in the glassy state
A Newman, G Zografi - Journal of Pharmaceutical Sciences, 2023 - Elsevier
In this Commentary, the authors expand on their earlier studies of the solid-state long-term
isothermal crystallization of amorphous API from the glassy state in amorphous solid …
isothermal crystallization of amorphous API from the glassy state in amorphous solid …
Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
T Chen, Q Li, G Ai, Z Huang, J Liu, L Zeng, Z Su… - Scientific Reports, 2024 - nature.com
Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective
properties. However, the poor water solubility of OBB hinders its release and absorption thus …
properties. However, the poor water solubility of OBB hinders its release and absorption thus …
Amorphous system of hesperetin and piperine—improvement of apparent solubility, permeability, and biological activities
The low bioaccessibility of hesperetin and piperine hampers their application as therapeutic
agents. Piperine has the ability to improve the bioavailability of many compounds when co …
agents. Piperine has the ability to improve the bioavailability of many compounds when co …
[HTML][HTML] Investigation of stabilized amorphous solid dispersions to improve oral olaparib absorption
T Yun, S Lee, S Yun, D Cho, K Bang, K Kim - Pharmaceutics, 2024 - mdpi.com
In this study, we investigated the formulation of stable solid dispersions to enhance the
bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer …
bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer …
Enhanced dissolution of sildenafil citrate using solid dispersion with hydrophilic polymers: physicochemical characterization and in vivo sexual behavior studies in …
Sildenafil citrate (SLC) is a frequently used medication (Viagra®) for the treatment of erectile
dysfunction (ED). Due to its poor solubility, SLC suffers from a delayed onset of action and …
dysfunction (ED). Due to its poor solubility, SLC suffers from a delayed onset of action and …
[HTML][HTML] Solubility and permeability enhancement of oleanolic acid by solid dispersion in poloxamers and γ-CD
C De Stefani, J Lodovichi, L Albonetti, MC Salvatici… - Molecules, 2022 - mdpi.com
Oleanolic acid (OA) is a pentacyclic triterpenoid widely found in the Oleaceae family, and it
represents 3.5% of the dry weight of olive leaves. OA has many pharmacological activities …
represents 3.5% of the dry weight of olive leaves. OA has many pharmacological activities …
[HTML][HTML] The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide
In this study, several experimental techniques were applied to probe thermal properties,
molecular dynamics, crystallization kinetics and intermolecular interactions in binary …
molecular dynamics, crystallization kinetics and intermolecular interactions in binary …
Preparation of astaxanthin‐loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability
Y Liao, H Wang, S Li, Y Xue, Y Chen… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Astaxanthin (AST) is approved by the US Food and Drug Administration
(FDA) as a safe dietary supplement for humans. As a potent lipid‐soluble keto‐carotenoid, it …
(FDA) as a safe dietary supplement for humans. As a potent lipid‐soluble keto‐carotenoid, it …