[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

3D printed oral solid dosage form: Modified release and improved solubility

N Wang, H Shi, S Yang - Journal of Controlled Release, 2022 - Elsevier
Oral solid dosage form is currently the most common used form of drug. 3D Printing, also
known as additive manufacturing (AM), can quickly print customized and individualized oral …

Considerations in the development of physically stable high drug load API-polymer amorphous solid dispersions in the glassy state

A Newman, G Zografi - Journal of Pharmaceutical Sciences, 2023 - Elsevier
In this Commentary, the authors expand on their earlier studies of the solid-state long-term
isothermal crystallization of amorphous API from the glassy state in amorphous solid …

Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4

T Chen, Q Li, G Ai, Z Huang, J Liu, L Zeng, Z Su… - Scientific Reports, 2024 - nature.com
Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective
properties. However, the poor water solubility of OBB hinders its release and absorption thus …

Amorphous system of hesperetin and piperine—improvement of apparent solubility, permeability, and biological activities

K Wdowiak, A Miklaszewski, R Pietrzak… - International Journal of …, 2023 - mdpi.com
The low bioaccessibility of hesperetin and piperine hampers their application as therapeutic
agents. Piperine has the ability to improve the bioavailability of many compounds when co …

[HTML][HTML] Investigation of stabilized amorphous solid dispersions to improve oral olaparib absorption

T Yun, S Lee, S Yun, D Cho, K Bang, K Kim - Pharmaceutics, 2024 - mdpi.com
In this study, we investigated the formulation of stable solid dispersions to enhance the
bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer …

[HTML][HTML] Solubility and permeability enhancement of oleanolic acid by solid dispersion in poloxamers and γ-CD

C De Stefani, J Lodovichi, L Albonetti, MC Salvatici… - Molecules, 2022 - mdpi.com
Oleanolic acid (OA) is a pentacyclic triterpenoid widely found in the Oleaceae family, and it
represents 3.5% of the dry weight of olive leaves. OA has many pharmacological activities …

[HTML][HTML] The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide

D Heczko, B Hachuła, P Maksym, K Kamiński, A Zięba… - Pharmaceuticals, 2022 - mdpi.com
In this study, several experimental techniques were applied to probe thermal properties,
molecular dynamics, crystallization kinetics and intermolecular interactions in binary …

Preparation of astaxanthin‐loaded composite micelles with coaxial electrospray technology for enhanced oral bioavailability and improved antioxidation capability

Y Liao, H Wang, S Li, Y Xue, Y Chen… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Astaxanthin (AST) is approved by the US Food and Drug Administration
(FDA) as a safe dietary supplement for humans. As a potent lipid‐soluble keto‐carotenoid, it …