The intricate relationship between immune dysregulation and neurodevelopmental
disorders (NDDs) has been observed across the stages of both prenatal and postnatal …

Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

Developmental alterations of excitatory synapses are implicated in autism spectrum
disorders (ASDs). Here, we report increased dendritic spine density with reduced …

Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various
genetic and environmental factors that result in synaptic abnormalities. ASD development is …

To assess the relative impact of inherited and de novo variants on autism risk, we generated
a comprehensive set of exonic single-nucleotide variants (SNVs) and copy number variants …

Autophagy is crucial for neuronal integrity. Loss of key autophagic components leads to
progressive neurodegeneration and structural defects in pre-and postsynaptic …

Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental
disorders with large genetic components, but identification of pathogenic genes has …

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders that are defined solely on the basis of behavioral observations. Therefore, ASD …