Ureases as multifunctional toxic proteins: A review

CR Carlini, R Ligabue-Braun - Toxicon, 2016 - Elsevier
Ureases are metalloenzymes that hydrolyze urea into ammonia and carbon dioxide. They
were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins …

[HTML][HTML] Plant ureases and related peptides: understanding their entomotoxic properties

F Stanisçuaski, CR Carlini - Toxins, 2012 - mdpi.com
Recently, ureases were included in the arsenal of plant defense proteins, alongside many
other proteins with biotechnological potential such as insecticides. Isoforms of Canavalia …

[HTML][HTML] Cloning and expression of protease ClpP from Streptococcus pneumoniae in Escherichia coli: study of the influence of kanamycin and IPTG concentration on …

K Einsfeldt, JBS Júnior, APC Argondizzo, MA Medeiros… - Vaccine, 2011 - Elsevier
Infections caused by Streptococcus pneumoniae are one of the main causes of death
around the world. In order to address this problem, investigations are being made into the …

Structure–function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease

AHS Martinelli, K Kappaun, R Ligabue-Braun… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Ureases are metalloenzymes involved in defense mechanisms in plants. The
insecticidal activity of Canavalia ensiformis (jack bean) ureases relies partially on an internal …

Toxic properties of urease

CR Carlini, JC Polacco - Crop Science, 2008 - Wiley Online Library
Plant ureases have long been known for their ureolytic activities, dependent on a Ni
metallocenter active site. We report here on more recently discovered novel toxic properties …

Fungitoxic and insecticidal plant polypeptides

AB Becker‐Ritt, CR Carlini - Peptide Science, 2012 - Wiley Online Library
Abstract According to the World Bank and FAO, the population grows worldwide and the
poorest countries are expected to double their population within the next decades …

Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases

MS Defferrari, DR Demartini, TB Marcelino… - Insect biochemistry and …, 2011 - Elsevier
Jackbean (Canavalia ensiformis) ureases are entomotoxic upon the release internal
peptides by insect's digestive enzymes. Here we studied the digestive peptidases of …

In vitro effect of Canavalia ensiformis urease and the derived peptide Jaburetox-2Ec on Rhodnius prolixus Malpighian tubules

F Stanisçuaski, V Te Brugge, CR Carlini… - Journal of Insect …, 2009 - Elsevier
Ureases are metalloenzymes that are widespread among plants, fungi and bacteria. Urease
isoforms (jack bean urease–JBU and canatoxin) from Canavalia ensiformis seeds are toxic …

Humoral and cellular immune responses induced by the urease-derived peptide Jaburetox in the model organism Rhodnius prolixus

LL Fruttero, NR Moyetta, AF Uberti, MVC Grahl… - Parasites & …, 2016 - Springer
Background Although the entomotoxicity of plant ureases has been reported almost 20
years ago, their insecticidal mechanism of action is still not well understood. Jaburetox is a …

Rhodnius prolixus intoxicated

RA Alzogaray, EN Zerba - Journal of insect physiology, 2017 - Elsevier
Abstract Rhodnius prolixus (Hemiptera: Reduviidae) is a hematophagous insect native from
South America. By the end of the 20th century, it was one of the main vectors of Chagas …