The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

Background Diabetic retinopathy is a major complication of diabetes mellitus, where in its
most advanced form ischemic changes lead to the development of retinal …

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been
discovered as a potent factor implicated in various inflammation-associated diseases …

Aims/hypothesis Diabetic retinopathy is a common complication of diabetes and a leading
cause of visual impairment and blindness. Despite recent advances, our understanding of its …

Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

S100A4, an important member of the S100 family of proteins, is best known for its significant
role in promoting cancer progression and metastasis. In addition to its expression in tumors …

The macrophage migration inhibitory factor (MIF)/CD74 signaling pathway is strongly
implicated in inflammation and angiogenesis. We investigated the expression of MIF and its …

Inflammation and fibrosis are key features of proliferative vitreoretinal disorders. We aimed
to define the macrophage phenotype and investigate the role of macrophage-myofibroblast …

Galectins are ten family members of carbohydrate-binding proteins with a high affinity for β
galactose-containing oligosaccharides. Galectin-1 (Gal-1) is the first protein discovered in …

Diabetic retinopathy was included by the World Health Organization in the eye disease
priority list. Up to now, only proliferative diabetic retinopathy can be treated with approved …