Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
JM Braun - Nature Reviews Endocrinology, 2017 - nature.com
Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by
disrupting hormone-mediated processes that are critical for growth and development during …
disrupting hormone-mediated processes that are critical for growth and development during …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Molecular mechanisms underlying chemical liver injury
X Gu, JE Manautou - Expert reviews in molecular medicine, 2012 - cambridge.org
The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
Ontogeny of hepatic transporters and drug-metabolizing enzymes in humans and in nonclinical species
BD Van Groen, J Nicolaï, AC Kuik… - Pharmacological …, 2021 - Elsevier
The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …
Trends in contraceptive prevalence rates in sub-Saharan Africa since the 2012 London Summit on Family Planning: results from repeated cross-sectional surveys
Summary Background The Family Planning 2020 (FP2020) initiative, launched at the 2012
London Summit on Family Planning, aims to enable 120 million additional women to use …
London Summit on Family Planning, aims to enable 120 million additional women to use …
Infantile internal and external exposure to neonicotinoid insecticides: a comparison of levels across various sources
H Zhang, Y Wang, H Zhu, S Lu, Y Wang… - Environmental …, 2023 - ACS Publications
Little is known about exposure of infants to neonicotinoid insecticides (NEOs). In this study,
concentrations of six parent NEOs (p-NEOs) and N-desmethyl-acetamiprid (N-dm-ACE) …
concentrations of six parent NEOs (p-NEOs) and N-desmethyl-acetamiprid (N-dm-ACE) …
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver
Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and
metabolic processes. Despite rapid progress in the understanding of these enzymes, a …
metabolic processes. Despite rapid progress in the understanding of these enzymes, a …
Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature
G Ginsberg, D Hattis, B Sonawane, A Russ… - Toxicological …, 2002 - academic.oup.com
Pharmacokinetics (PK) of xenobiotics can differ widely between children and adults due to
physiological differences and the immaturity of enzyme systems and clearance mechanisms …
physiological differences and the immaturity of enzyme systems and clearance mechanisms …
Obesity and endocrine-disrupting chemicals
Obesity is now a worldwide pandemic. The usual explanation given for the prevalence of
obesity is that it results from consumption of a calorie dense diet coupled with physical …
obesity is that it results from consumption of a calorie dense diet coupled with physical …