With the increase in the aging population, the occurrence of neurological disorders is rising.
Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal …

Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical
and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for …

Ischemic stroke is a leading cause of mortality and long-term disability globally. One of its
aspects is the breakdown of the blood-brain barrier (BBB). The disruption of BBB's integrity …

After cerebral ischemia, the brain encounters noxious stimuli that result in a dysfunctional
balance between the production and elimination of reactive oxygen species, which in turn …

The etiology and mechanisms of ischemic stroke are complex, encompassing a variety of
pathological processes including atherosclerosis, energy failure, neuroinflammation, blood …

Bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs),
especially small EVs (sEVs), were vastly reported to enable multiple restorative effects on …

Background Mounting data indicates that extracellular vesicles (EVs) have the potential to
improve the injury after a stroke. Pyroptosis is a recently identified kind of programmed cell …

细胞外囊泡是一种天然的纳米载药体, 在体内具有良好的生物相容性, 在缺血性脑卒中治疗中
具有显著优势. 然而, 细胞外囊泡的分布不确定和快速清除阻碍了其给药效率. 令人鼓舞的是 …

Abstract [eng] Blood-brain barrier (BBB) controls the molecular exchange between the brain
parenchyma and blood circulation, and prevents the entry of toxins, pathogens, inflammatory …

Intrathecal administration of human umbilical cord mesenchymal stem cells may be a
promising approach for the treatment of stroke, but its safety, effectiveness, and mechanism …