Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

Exploring the NK cell platform for cancer immunotherapy

JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

A review of Glycogen Synthase Kinase-3 (GSK3) inhibitors for cancers therapies

R Thapa, G Gupta, AA Bhat, WH Almalki… - International journal of …, 2023 - Elsevier
The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells

B Ruf, B Heinrich, TF Greten - Cellular & molecular immunology, 2021 - nature.com
Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …

Influence of the tumor microenvironment on NK cell function in solid tumors

O Melaiu, V Lucarini, L Cifaldi, D Fruci - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Immunometabolism and natural killer cell responses

KL O'Brien, DK Finlay - Nature Reviews Immunology, 2019 - nature.com
Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune
responses to tumours and viral infection. However, in certain chronic diseases, including …

WNT signaling in cancer immunosurveillance

L Galluzzi, S Spranger, E Fuchs, A López-Soto - Trends in cell biology, 2019 - cell.com
Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …