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The oxytocin receptor: from intracellular signaling to behavior
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity
Gonadal hormones play a key role in the establishment, activation, and regulation of the
hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to …
hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to …
Stress and the social brain: behavioural effects and neurobiological mechanisms
Stress often affects our social lives. When undergoing high-level or persistent stress,
individuals frequently retract from social interactions and become irritable and hostile …
individuals frequently retract from social interactions and become irritable and hostile …
[HTML][HTML] Roles of oxytocin in stress responses, allostasis and resilience
Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …
[HTML][HTML] Oxytocin in general anxiety and social fear: a translational approach
The neuropeptide oxytocin (OXT) has been revealed as a profound anxiolytic and antistress
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …
factor of the brain, besides its many prosocial and reproductive effects. Therefore, there is …
Psychobiological mechanisms underlying the social buffering of the hypothalamic–pituitary–adrenocortical axis: A review of animal models and human studies across …
Discovering the stress-buffering effects of social relationships has been one of the major
findings in psychobiology in the last century. However, an understanding of the underlying …
findings in psychobiology in the last century. However, an understanding of the underlying …
[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …
Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight.
The human stress response has been characterized, both physiologically and behaviorally,
as “fight-or-flight.” Although fight-or-flight may characterize the primary physiological …
as “fight-or-flight.” Although fight-or-flight may characterize the primary physiological …
The oxytocin receptor system: structure, function, and regulation
G Gimpl, F Fahrenholz - Physiological reviews, 2001 - journals.physiology.org
The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in
all vertebrates at several levels. The major site of OT gene expression is the magnocellular …
all vertebrates at several levels. The major site of OT gene expression is the magnocellular …