'Liking'and 'wanting'in eating and food reward: Brain mechanisms and clinical implications
It is becoming clearer how neurobiological mechanisms generate 'liking'and
'wanting'components of food reward. Mesocorticolimbic mechanisms that enhance …
'wanting'components of food reward. Mesocorticolimbic mechanisms that enhance …
Striatal circuits for reward learning and decision-making
The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …
those actions. Decades of experimental and theoretical work have led to several influential …
Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data
In vivo calcium imaging through microendoscopic lenses enables imaging of previously
inaccessible neuronal populations deep within the brains of freely moving animals …
inaccessible neuronal populations deep within the brains of freely moving animals …
The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding
The basal ganglia are known to control actions and modulate movements. Neuronal activity
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …
in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral …
[HTML][HTML] The meaning of behavior: discriminating reflex and volition in the brain
The ability to establish behaviorally what psychological capacity an animal is deploying—to
discern accurately what an animal is doing—is key to functional analyses of the brain. Our …
discern accurately what an animal is doing—is key to functional analyses of the brain. Our …
Ventral hippocampal projections to the medial prefrontal cortex regulate social memory
Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
Fast and accurate sCMOS noise correction for fluorescence microscopy
The rapid development of scientific CMOS (sCMOS) technology has greatly advanced
optical microscopy for biomedical research with superior sensitivity, resolution, field-of-view …
optical microscopy for biomedical research with superior sensitivity, resolution, field-of-view …
Natural locus coeruleus dynamics during feeding
Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are
required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity …
required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity …
Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons
LM Requie, M Gómez-Gonzalo, M Speggiorin… - Nature …, 2022 - nature.com
The plasticity of glutamatergic transmission in the ventral tegmental area (VTA) represents a
fundamental mechanism in the modulation of dopamine neuron burst firing and phasic …
fundamental mechanism in the modulation of dopamine neuron burst firing and phasic …