Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Careful regulation of the complement system is critical for enabling complement proteins to
titrate immune defense while also preventing collateral tissue damage from poorly controlled …

Purpose: To study the levels of complement activation in different disease stages of AMD
and the influence of genetic polymorphisms in complement genes. Methods: We included …

The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

Outer retinal and renal glomerular functions rely on specialized vasculature maintained by
VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) …

The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …