Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Candidate biomarkers in psychiatric disorders: state of the field

A Abi‐Dargham, SJ Moeller, F Ali… - World …, 2023 - Wiley Online Library
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

[HTML][HTML] Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

T Behl, T Rana, GH Alotaibi, M Shamsuzzaman… - Biomedicine & …, 2022 - Elsevier
Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology

EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Oxidative stress and the central nervous system

S Salim - The Journal of pharmacology and experimental …, 2017 - Elsevier
Biochemical integrity of the brain is vital for normal functioning of the central nervous system
(CNS). One of the factors contributing to cerebral biochemical impairment is a chemical …

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

S Masaldan, AI Bush, D Devos, AS Rolland… - Free Radical Biology …, 2019 - Elsevier
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

Mechanistic insights into the link between gut dysbiosis and major depression: an extensive review

S Sonali, B Ray, H Ahmed Tousif, AG Rathipriya… - Cells, 2022 - mdpi.com
Depression is a highly common mental disorder, which is often multifactorial with sex,
genetic, environmental, and/or psychological causes. Recent advancements in biomedical …

[HTML][HTML] Nrf2: An all-rounder in depression

C Zuo, H Cao, Y Song, Z Gu, Y Huang, Y Yang, J Miao… - Redox biology, 2022 - Elsevier
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

[HTML][HTML] Neuroinflammation in schizophrenia: the key role of the WNT/β-catenin pathway

A Vallée - International Journal of Molecular Sciences, 2022 - mdpi.com
Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …