Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

For two decades, diversity-oriented synthesis (DOS) has facilitated the assembly of small-
molecule libraries comprising a variety of complex molecular architectures. Here, we …

Medium-sized heterocycles (with 8 to 11 atoms) constitute important structural components
of several biologically active natural compounds and represent promising scaffolds in …

Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …

Fragment-based drug discovery (FBDD) is a well-established approach for the discovery of
novel medicines, illustrated by the approval of two FBBD-derived drugs. This methodology is …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

The publications covering new, transition metal-free cross-coupling reactions of pyrroles
with electrophilic haloacetylenes in solid medium of metal oxides and salts to …

Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with
underrepresented features in commercial screening collections, resulting in the elucidation …