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Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …
and are a vital part of the innate immune system for host defense against many pathogens …
[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
Targeting metabolic dysregulation for fibrosis therapy
Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …
Immunometabolism at the interface between macrophages and pathogens
It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …
consequence of a failed immune response. However, recent appreciation of macrophage …
Eicosanoid storm in infection and inflammation
Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …
Carcinogenesis: Failure of resolution of inflammation?
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …
key characteristic of carcinogens. However, the failure of resolution of inflammation in …
[HTML][HTML] Exploration and development of PPAR modulators in health and disease: an update of clinical evidence
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the
expression of genes responsible for energy metabolism, cellular development, and …
expression of genes responsible for energy metabolism, cellular development, and …
Regulation of ketone body metabolism and the role of PPARα
M Grabacka, M Pierzchalska, M Dean… - International journal of …, 2016 - mdpi.com
Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …
Regulation of energy metabolism by long-chain fatty acids
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …
energy demands arise. This review mainly focuses on the role of long chain fatty acids …