The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …

Aluminum (Al), as a common environmental pollutant, causes osteoblast (OB) dysfunction
and then leads to Al-related bone diseases (ARBD). One of the mechanisms of ARBD is …

Autophagy is a cellular recycling process involving self-degradation and reconstruction of
damaged organelles and proteins. Current evidence suggests that autophagy is critical in …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Significance: Autophagy and apoptosis are two important cellular mechanisms behind brain
injuries, which are severe clinical situations with increasing incidences worldwide. To …

Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea
is a popular beverage (rich in polyphenols) with abundant health promoting and disease …

Aging is a natural biological process that manifests as the progressive loss of function in
cells, tissues, and organs. Because mechanisms that are meant to promote cellular longevity …

The repositioning of therapeutic agents already approved by the regulatory agencies for the
use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of …