The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Background Flavonols are one of the most promising class of bioactive compounds
belonging to the broad family of the flavonoids, characterized by a unique set of features in …

Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …

Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Aluminum (Al), as a common environmental pollutant, causes osteoblast (OB) dysfunction
and then leads to Al-related bone diseases (ARBD). One of the mechanisms of ARBD is …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Autophagy is a cellular recycling process involving self-degradation and reconstruction of
damaged organelles and proteins. Current evidence suggests that autophagy is critical in …

Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

The repositioning of therapeutic agents already approved by the regulatory agencies for the
use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of …

Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …