Due to their high specificity, monoclonal antibodies have been widely investigated for their
application in drug delivery to the central nervous system (CNS) for the treatment of …

Highlights•Molecular systems behavior differs fundamentally under biochemical vs native
cellular conditions.•Many binding sites (including those of drug targets) build and decay over …

Controlling the viscosity of concentrated protein solutions–usually reducing–is an open
challenge, with major recent relevance in protein formulations for biopharmaceutical …

The SARS-CoV-2 main protease (Mpro) is of major interest as an antiviral drug target.
Structure-based virtual screening efforts, fueled by a growing list of apo and inhibitor-bound …

The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as
hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr) …

The membrane dipole potential (Ψ d) constitutes one of three electrical potentials generated
by cell membranes. Ψ d arises from the unfavorable parallel alignment of phospholipid and …

Abstract Treatment targeting osteopontin (OPN) and monocyte chemoattractant protein 1
(MCP‑1) has been recognized as a novel approach in renal crystal formation. The present …

Cellular function depends on heterogeneous dynamic intra-, inter-, and supramolecular
structure-function relationships. However, the specific mechanisms by which cellular …

Achieving cell permeability and oral bioavailability are key challenges for peptide
therapeutics. In this chapter, we review the evolution of and recent advances in rational …

Cellular functions are executed via a form of analog computing that is based on the
switchable covalent and non-covalent states of multi-molecular fluxes (ie, time-dependent …