Importance Stimulant use disorder is common, affecting between 0.3% and 1.1% of the
population, and costs more than $85 billion per year globally. There are no licensed …

Parkinson's disease is a devastating neurological condition that affects at least four million
people. A striking feature of this disorder is the preferential loss of dopamine-producing …

Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …

Methamphetamine (METH) is an illicit psychostimulant that is widely abused in the world.
Several lines of evidence suggest that chronic METH abuse leads to neurodegenerative …

Oxygen is an essential element for normal life. However, reactive oxygen species (ROS) can
also participate in deleterious reactions that can affect lipid, protein, and nucleic acid …

Research into methamphetamine-induced neurotoxicity has experienced a resurgence in
recent years. This is due to (1) greater understanding of the mechanisms underlying …

Methamphetamine-induced toxicity has been shown to require striatal dopamine and to
involve mechanisms associated with oxidative stress. Dopamine is a reactive molecule that …

Animal models are an important aid in experimental medical science because they enable
one to study the pathogenetic mechanisms and the therapeutic principles of treating the …

Methamphetamine (MA) abuse is increasing to epidemic proportions, both nationally and
globally. Chronic MA use has been linked to significant impairments in different arenas of …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …