Heme is a complex of iron with protoporphyrin IX that is essential for the function of all
aerobic cells. Heme serves as the prosthetic group of numerous hemoproteins (eg …

Despite its abundance in the earth's crust, iron deficiency is a serious health issue in many
parts of the world. Although fundamental observations about iron metabolism and the …

Background The cytochrome P-450 superfamily is comprised of at least 27 distinct gene
families, 10 of which are found in mammals (Nebert et al., 1991; Gonzalez, 1990). P-450 …

Publisher Summary Many of these P450 enzymes have specific roles in the anabolism of
steroids. The P450 enzymes that oxidize drugs are localized in the liver, although some …

Heme metabolism normally involves enzymatic conversion to biliverdin and subsequently to
bilirubin, catalyzed by heme oxygenase and biliverdin reductase, respectively. We …

Haem has long been known as the prosthetic group of haemoproteins such as
haemoglobin, catalase and the cytochromes. Its biosynthesis is regulated by feedback …

When I began this review my goal was to present a coherent overview of the biochemistry
and regulation of the inducible P450 cytochromes of bacteria. Now, at the end, I wonder if a …

Aquatic Toxicology examines research findings on the chronic effects of pollutants on
aquatic species. Understanding these chronic effects is vital to determining the impact of …

Heme is vital to our aerobic universe. Heme cellular content is finely tuned through an
exquisite control of synthesis and degradation. Heme deficiency is deleterious to cells …

The major cytochrome P450 in the yeast Saccharomyces cerevisiae, lanosterol 14 alpha-
demethylase (ERG11), catalyzes an essential reaction in the biosynthesis of ergosterol, the …