Blood vessels and nerve fibres course throughout the body in an orderly pattern, often
alongside one another. Although superficially distinct, the mechanisms involved in wiring …

Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or
severe visual impairment before the age of 1 year. Linkage analysis, homozygosity map** …

The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the develo** nervous system …

Growth cones contain mRNAs, translation machinery, and, as we report here, protein
degradation machinery. We show that isolated retinal growth cones immediately lose their …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

Proper patterning of the nervous system requires that develo** axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

Blood vessels and nerves are complex, branched structures that share a high degree of
anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to …

Netrin-1 is known to function as a chemoattractant for several classes of develo** axons
and as a chemorepellent for other classes of axons, apparently dependent on the receptor …