Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal
transducers. They regulate essential cellular processes like proliferation, apoptosis …

(1) Background: The oncology field has drastically changed with the advent of precision
medicine, led by the discovery of druggable genes or immune targets assessed through next …

Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …

Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes
ranging from embryogenesis to wound healing and has strong links to several hallmarks of …

As tumours evolve, the daughter cells of the initiating cell often become molecularly
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …

Purpose JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor
(FGFR) tyrosine kinase inhibitor. This first-in-human study evaluates the safety …

Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …

Cancer is the leading cause of death worldwide; thus, it is necessary to find successful
strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic …