The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their
own growth and evade chemotherapy. Here, we provide evidence that acute myeloid …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic
and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and …

Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche
to maintain their quiescence and adapt blood production to the organism's needs …

Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are
part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) …

Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the
haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired …

ELDA is a software application for limiting dilution analysis (LDA), with particular attention to
the needs of stem cell assays. It is the first limiting dilution analysis software to provide …

Mesenchymal stem cells (MSCs) commonly defined by in vitro functions have entered
clinical application despite little definition of their function in residence. Here, we report …