Natural products: A lead for drug discovery and development

B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …

Targeting NF-κB signaling pathway in cancer by dietary polyphenols

H Khan, H Ullah, PCMF Castilho… - Critical Reviews in …, 2020 - Taylor & Francis
Being a transcription factor, NF-κB regulates gene expressions involving cell survival and
proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a …

An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System

I Jantan, MA Haque, M Ilangkovan… - Frontiers in …, 2019 - frontiersin.org
Phyllanthus species (family; Euphorbiaceae) have been intensively studied for their
immunomodulating effects due to their wide-ranging uses to treat immune-related diseases …

Anti-inflammatory effects of four psilocybin-containing magic mushroom water extracts in vitro on 15-lipoxygenase activity and on lipopolysaccharide-induced …

SM Nkadimeng, CML Steinmann… - Journal of Inflammation …, 2021 - Taylor & Francis
Purpose During a pathological inflammation, macrophages are activated to produce
accumulation of inflammatory mediators such as induced-cyclooxygenase-2 (COX-2), 15 …

Critical review on anti‐inflammation effects of saponins and their molecular mechanisms

T Wijesekara, J Luo, B Xu - Phytotherapy Research, 2024 - Wiley Online Library
This review highlights the increasing interest in one of the natural compounds called
saponins, for their potential therapeutic applications in addressing inflammation which is a …

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (sco** review)

M Kalachaveedu, R Senthil… - Phytotherapy …, 2023 - Wiley Online Library
Emerging evidence on molecular biology related to tumors, inflammation, and immunity,
highlights their architectural commonality shifting cancer treatment paradigms toward more …

The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages

M Zaiachuk, SV Suryavanshi, N Pryimak, I Kovalchuk… - Molecules, 2023 - mdpi.com
Inflammation is the response of the innate immune system to any type of injury. Although
acute inflammation is critical for survival, dysregulation of the innate immune response leads …

Deciphering psilocybin: Cytotoxicity, anti-inflammatory effects, and mechanistic insights

S Laabi, C LeMmon, C Vogel, M Chacon… - International …, 2024 - Elsevier
A decade of clinical research has indicated psilocybin's effectiveness in treating various
neuropsychiatric disorders, such as depression and substance abuse. The correlation …

Exploring the potential of treating chronic liver disease targeting the PI3K/Akt pathway and polarization mechanism of macrophages

Y Yang, X Jia, M Qu, X Yang, Y Fang, X Ying, M Zhang… - Heliyon, 2023 - cell.com
Chronic liver disease is a significant public health issue that can lead to considerable
morbidity and mortality, imposing an enormous burden on healthcare resources …

Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19

R Singh, S Goel, P Bourgeade, L Aleya… - … Science and Pollution …, 2021 - Springer
Abstract Coronavirus disease (COVID-19) has been declared as a pandemic by the World
Health Organization with rapid spread across 216 countries. COVID-19 pandemic has left its …