The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …

Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …

Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …

ABC (ATP-binding cassette) transporters represent one of the largest and most diverse
superfamily of proteins in living species, playing an important role in many biological …

Effective treatments for primary brain tumors and brain metastases represent a major unmet
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …

The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …