T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase
(HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) …

Simple Summary Immunotherapy is currently the backbone of new drug treatments for many
cancer patients. CXC chemokine ligand 13 (CXCL13) is an important factor involved in …

T follicular helper (TFH) cells are specialized effector CD4+ T cells critical to humoral
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …

During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a …

CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune
clearance of infected and cancerous cells and provide long-term protection. Recent …

Recent findings demonstrated proinflammatory functions of interleukin (IL)-9–producing T
helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However …

Background Rheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune
disease in which TB interactions play a critical role. Recent comprehensive analysis …

Different dynamics of gene expression are observed during cell differentiation. In T cells,
genes that are turned on early or turned off and stay off have been thoroughly studied …

Background Autoantibody production against endogenous cellular components is
pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (T FH) cells …