Abstract Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear
magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and …

The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key
physiological processes and thus have long been attractive drug targets. With the crystal …

Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCRs)
govern a wide range of vital physiological processes, making GPCRs prominent drug …

Highlights•A public–private partnership targets drug-binding kinetics in a multilevel
approach.•New experimental approaches for measuring drug residence time are …

The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the
long, costly process of bringing a new medicine to patients. For example, the time a drug …

When characterizing biomolecular interactions, avidity, is an umbrella term used to describe
the accumulated strength of multiple specific and unspecific interactions between two or …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Historically, the main barrier to membrane protein investigations has been the tendency of
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …