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Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …
Head and neck squamous cell carcinoma
Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …
NK cells for cancer immunotherapy
N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …
associated with oncogenic transformation. This property, which is unique among immune …
Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma
A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …
characterized by high morbidity and low survival rates with limited therapeutic options …
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) undergoes stepwise progression from
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …
Neoadjuvant chemo-immunotherapy with camrelizumab plus nab-paclitaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and …
D Wu, Y Li, P Xu, Q Fang, F Cao, H Lin, Y Li… - Nature …, 2024 - nature.com
Neoadjuvant chemoimmunotherapy has emerged as a potential treatment option for
resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II …
resectable head and neck squamous cell carcinoma (HNSCC). In this single-arm phase II …
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
BACKGROUND. PD-L1 expression and tumor mutational burden (TMB) have emerged as
important biomarkers of response to immune checkpoint inhibitor (ICI) therapy. These …
important biomarkers of response to immune checkpoint inhibitor (ICI) therapy. These …
Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …